Recent Journal Publications
2019

Jeong HH, Kim SY, Rousseaux MW, Zoghbi HY, Liu Z. Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives. Genome Research 2019 Apr 23 DOI: 10.1101/gr.245571.118

2018

Rousseaux MW*#, Vazquez-Velez GE*, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez A, Kim JY, Lavery LA, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY#. A druggable genome screen identifies modifiers of alpha-synuclein levels via a tiered cross-species validation approach. J. Neurosci. 2018 Sep 24 DOI: https://doi.org/10.1523/JNEUROSCI.0254-18.2018

* = Authors contributed equally

# = Co-corresponding authors

Cover article

Rousseaux MW, Revelli JP, Vazquez-Velez GE, Kim JY, Craigen E, Gonzales K, Beckinghausen J, Zoghbi HY. Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and taueLife  2018 Jun 4 10.7554/eLife.36768

Rousseaux MW*, Tschumperlin T*, Lu HC*, Lackey EP, Bondar V, Wan YW, Tan Q, Adamski CJ, Friedrich J, Twaroski K, Chen W,  Tolar J, Henzler C, Sharma A, Bajic A, Lin T, Duvick L, Liu Z, Sillitoe RV, Zoghbi HY, Orr HT. ATXN1-CIC complex is the primary driver of cerebellar pathology in spinocerebellar ataxia type 1 through a gain-of-function mechanism. Neuron. 2018 Mar 21. https://doi.org/10.1016/j.neuron.2018.02.013

* = Authors contributed equally

Tan Q, Brunetti L, Rousseaux MW, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HY. Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. PNAS Jan 30. doi: 10.1073/pnas.1716452115.

2017

Jeong HH, Kim SY, Rousseaux MW, Zoghbi HY, Liu Z. CRISPRcloud: a secure cloud-based pipeline for CRISPR pooled screen deconvolution. Bioinformatics. 2017 Sep 15. doi: 10.1093/bioinformatics/btx335. 

Rousseaux MW, Shulman JM, Jankovic J. Progress toward an integrated understanding of Parkinson's disease. F1000Res. 2017 Jul 12. doi: 10.12688/f1000research.11820.1.

Jung SY*, Choi JM*, Rousseaux MW*, Malovannaya A, Kim JJ, Kutzera J, Wang Y, Huang Y, Zhu W, Maity S, Zoghbi HY, Qin J. An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways. Mol. Cell. Proteomics. 2017 Apr. doi: 10.1074/mcp.M116.061440.

* = Authors contributed equally

Lu HC*, Tan Q*, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY.Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat. Genet. 2017 Apr. doi: 10.1038/ng.3808.

* = Authors contributed equally

2016

Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. eLife. 2016 Oct 25. doi: 10.7554/eLife.19809.

Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19. doi: 10.1016/j.neuron.2016.09.022. 

For an updated list of Dr. Rousseaux's published works, please see Pubmed and Google Scholar listings.

PUBLICATIONS

The University of Ottawa

Brain and Mind Research Institute

© 2018 by M. Rousseaux

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