Recent Journal Publications

Suk TR and Rousseaux MW. The role of TDP-43 mislocalization in amyotrophic lateral sclerosis Molecular Neurodegeneration 2020 Aug 15 doi:

Geertsma HM and Rousseaux MW. Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease EBioMed 2020 Jan 22 doi:


Vazquez-Velez GE, Gonzales KA, Revelli JP, Adamski CA, Alavi Naini F, Bajic A, Heman-Ackah SM, Wood MJA, Rousseaux MW, Zoghbi HY. Doublecortin like kinase 1 regulates α-synuclein levels and toxicity. J. Neurosci. 2019 Nov 20 doi: 10.1523/JNEUROSCI.1076-19.2019

Jeong HH, Kim SY, Rousseaux MW, Zoghbi HY, Liu Z. Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives. Genome Research 2019 Apr 23 DOI: 10.1101/gr.245571.118


Rousseaux MW*#, Vazquez-Velez GE*, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez A, Kim JY, Lavery LA, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY#. A druggable genome screen identifies modifiers of alpha-synuclein levels via a tiered cross-species validation approach. J. Neurosci. 2018 Sep 24 DOI:

* = Authors contributed equally

# = Co-corresponding authors

Cover article

Rousseaux MW, Revelli JP, Vazquez-Velez GE, Kim JY, Craigen E, Gonzales K, Beckinghausen J, Zoghbi HY. Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and taueLife  2018 Jun 4 10.7554/eLife.36768

Rousseaux MW*, Tschumperlin T*, Lu HC*, Lackey EP, Bondar V, Wan YW, Tan Q, Adamski CJ, Friedrich J, Twaroski K, Chen W,  Tolar J, Henzler C, Sharma A, Bajic A, Lin T, Duvick L, Liu Z, Sillitoe RV, Zoghbi HY, Orr HT. ATXN1-CIC complex is the primary driver of cerebellar pathology in spinocerebellar ataxia type 1 through a gain-of-function mechanism. Neuron. 2018 Mar 21.

* = Authors contributed equally

Tan Q, Brunetti L, Rousseaux MW, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HY. Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. PNAS Jan 30. doi: 10.1073/pnas.1716452115.


Jeong HH, Kim SY, Rousseaux MW, Zoghbi HY, Liu Z. CRISPRcloud: a secure cloud-based pipeline for CRISPR pooled screen deconvolution. Bioinformatics. 2017 Sep 15. doi: 10.1093/bioinformatics/btx335. 

Rousseaux MW, Shulman JM, Jankovic J. Progress toward an integrated understanding of Parkinson's disease. F1000Res. 2017 Jul 12. doi: 10.12688/f1000research.11820.1.

Jung SY*, Choi JM*, Rousseaux MW*, Malovannaya A, Kim JJ, Kutzera J, Wang Y, Huang Y, Zhu W, Maity S, Zoghbi HY, Qin J. An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways. Mol. Cell. Proteomics. 2017 Apr. doi: 10.1074/mcp.M116.061440.

* = Authors contributed equally

Lu HC*, Tan Q*, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY.Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat. Genet. 2017 Apr. doi: 10.1038/ng.3808.

* = Authors contributed equally


Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. eLife. 2016 Oct 25. doi: 10.7554/eLife.19809.

Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19. doi: 10.1016/j.neuron.2016.09.022. 

For an updated list of Dr. Rousseaux's published works, please see Pubmed and Google Scholar listings.


The University of Ottawa

Brain and Mind Research Institute

© 2020 by M. Rousseaux

  • Twitter Social Icon
  • LinkedIn Social Icon
This site was designed with the
website builder. Create your website today.
Start Now